Dr. Mead initially worked in the Professorial Hepatology and Gastroenterology unit at the Royal Free Hospital before moving closer to his family in Dorset and Hampshire. Whilst training as a specialist Gastroenterologist he spent 6 years in 4 national centres of excellence, including Southampton University and Cambridge University hospitals. He researched into the early detection of oesophageal and colorectal cancers, becoming an academic Doctor of Medicine in 2013. In the last year before taking up his Consultant post in the East and North Hertfordshire NHS Trust he practiced at Addenbrooke's Hospital Cambridge, focusing on endoscopy and inflammatory bowel disease.
Endoscopy has been a long held interest of his, with fellowships in Queen Alexandra Hospital Portsmouth, a national centre of excellence and in Tokyo, Japan, a world centre of endoscopic excellence. He has published on endoscopic techniques in the upper and lower gut. He is responsible for teaching endoscopy to Gastroenterology trainees and is a faculty member and lecturer on courses teaching advanced endoscopic techniques.